Kirkland, Thomas A. published the artcileSynthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Bioorganic & Medicinal Chemistry (2008), 16(9), 4963-4983, database is CAplus and MEDLINE.
Leukotriene B4 (LTB4) is a potent pro-inflammatory mediator that has been implicated in the pathogenesis of multiple diseases, including psoriasis, inflammatory bowel disease, multiple sclerosis and asthma. As a method to decrease the level of LTB4 and possibly identify novel treatments, inhibitors of the LTB4 biosynthetic enzyme, leukotriene A4 hydrolase (LTA4-h), have been explored. Here, the authors describe the discovery of a potent inhibitor of LTA4-h, arylamide of glutamic acid derivative I, starting from Boc-Glu[NHC6H4(OCH2Ph)-4]-OH. Analogs of I are then described, focusing on compounds that are both active and stable in whole blood. This effort culminated in the identification of amino alc. II and amino ester III which meet these criteria.
Bioorganic & Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.
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