Hoegl, Annabelle et al. published their research in Nature Chemistry in 2018 | CAS: 65-22-5

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 65-22-5

Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics was written by Hoegl, Annabelle;Nodwell, Matthew B.;Kirsch, Volker C.;Bach, Nina C.;Pfanzelt, Martin;Stahl, Matthias;Schneider, Sabine;Sieber, Stephan A.. And the article was included in Nature Chemistry in 2018.SDS of cas: 65-22-5 The following contents are mentioned in the article:

Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chem. transformation of biol. amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homol. challenging. Here we present a chem. proteomic method for reporting on PLP-DEs using functionalized cofactor probes. We synthesized pyridoxal analogs modified at the 2′-position, which are taken up by cells and metabolized in situ. These pyridoxal analogs are phosphorylated to functional cofactor surrogates by cellular pyridoxal kinases and bind to PLP-DEs via an aldimine bond which can be rendered irreversible by NaBH4 reduction Conjugation to a reporter tag enables the subsequent identification of PLP-DEs using quant., label-free mass spectrometry. Using these probes we accessed a significant portion of the Staphylococcus aureus PLP-DE proteome (73%) and annotate uncharacterized proteins as novel PLP-DEs. We also show that this approach can be used to study structural tolerance within PLP-DE active sites and to screen for off-targets of the PLP-DE inhibitor D-cycloserine. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts