Tin(IV) Schiff base complexes derived from pyridoxal: Synthesis, spectroscopic properties and cytotoxicity was written by Galvan-Hidalgo, Jose M.;Chans, Guillermo M.;Ramirez-Apan, Teresa;Nieto-Camacho, Antonio;Hernandez-Ortega, Simon;Gomez, Elizabeth. And the article was included in Applied Organometallic Chemistry in 2017.Product Details of 65-22-5 The following contents are mentioned in the article:
The synthesis of monomeric pentacoordinated diorganotin(IV) complexes derived from pyridoxal hydrochloride and 4- or 5-R-substituted ortho-aminophenols is described. The complexes were characterized using UV-visible, IR, mass, 1H NMR, 13C NMR and 119Sn NMR spectral techniques. The mol. structure of three complexes was established using X-ray diffraction: two complexes show a distorted trigonal bipyramidal geometry, in which the basal plane is defined by the Bu groups and the iminic nitrogen atom, whereas the oxygen atoms from the aromatic ring occupy axial positions; in contrast, another complex exhibits a square pyramidal geometry. The cytotoxic activity of all complexes against human cell lines U-251 (glioblastoma), K-562 (chronic myelogenous leukemia), HCT-15 (human colorectal cancer), MCF-7 (human breast cancer) and SKLU-1 (non-small-cell lung cancer) was evaluated, and the inhibitory percentage values indicated higher activity than the reference standard, cisplatin. Acute toxicity studies were performed in vivo for the prepared complexes to determine the lethal medium dose (LD50) after i.p. administration to mice. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Product Details of 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts