Synthesis, structural characterization and antioxidant activity of some vanadium(IV), Mo(VI)/(IV) and Ru(II) complexes of pyridoxal Schiff base derivatives was written by Elsayed, Shadia A.;Noufal, Aya M.;El-Hendawy, Ahmed M.. And the article was included in Journal of Molecular Structure in 2017.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
New complexes containing vanadium(IV), Mo(VI)/(IV) and Ru(II) derived from Schiff base of pyridoxal and S-benzyldithiocarbazate (H2pysb) or p-toluidine (Hpytol) have been prepared The structures of the described compounds were elucidated by elemental analyses, spectroscopic techniques (IR, 1H NMR, UV-Vis and EPR) magnetism, molar conductivity and thermal anal. measurements. Their redox behaviors were also studied by cyclic voltammetry. The ligand H2pysb showed coordination to the metal ions in a dibasic tridenate manner through deprotonated phenolate oxygen, azomethine nitrogen and thiolate sulfur, while Hpytol behaved as monobasic bidentate through phenolate oxygen and azomethine nitrogen. The complexes were tested for their antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and the data obtained revealed that the scavenging activity of the complexes towards DPPH is high for the oxovanadium(IV) complexes with lower IC50 values which are comparable to ascorbic acid as a standard antioxidant. The EC50 concentration ratio together with other antioxidant parameters are also reported. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts