Development and validation of a method for determination of 17 endocrine disrupting chemicals in milk, water, blood serum and feed by UHPLC-MS/MS was written by Di Marco Pisciottano, Ilaria;Albrizio, Stefania;Guadagnuolo, Grazia;Gallo, Pasquale. And the article was included in Food Additives & Contaminants, Part A in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:
The concern for human exposure to bisphenol A (BPA) has led to the introduction of other bisphenols to be used as substitutes in industrial processes. These compounds show activity similar to BPA as endocrine disruptors and could be already widespread both in the environment and in food. To monitor their possible occurrence in the food chain, an anal. method based on affinity chromatog. clean-up and UHPLC coupled to tandem mass spectrometry detection was developed and inhouse validated according to European law, for simultaneous determination of 17 bisphenols in milk and blood serum from bovine and buffalo, in drinking water and in feed. The anal. performance parameters of the method for these matrixes were determined The results showed satisfactory precision in terms of relative standard deviation (3.3%-21.4%), overall good trueness as mean percentage recoveries (77.0%-119.4%), with the only exception of bisphenol PH and bisphenol S in milk and BPA diglycidyl ether in serum. The high specificity and sensitivity of the method allowed us to determine the analytes at very low concentrations, i.e., 0.01-1.0 ng/mL in water, 0.1-2.0 ng/mL in milk, 0.01-1.0 ng/g in blood serum and 1.0-10.0 ng/g in feed. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 4,4′-Methylenediphenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts