Bottari, Giovanni published the artcileSynthesis of Enantioenriched Amines by Iron-Catalysed Amination of Alcohols Employing at Least One Achiral Substrate, Application In Synthesis of 111-29-5, the publication is Advanced Synthesis & Catalysis (2021), 363(24), 5436-5442, database is CAplus.
The synthesis of a broad range of enantioenriched amines by the direct Fe-catalyzed coupling of amines with alcs. through the borrowing hydrogen strategy, while at least one of these substrates was achiral is reported. When starting from α-chiral amines and achiral alcs., a wide range of enantioenriched amine products, including N-heterocyclic moieties was obtained with complete retention of stereochem.. The power of this method was demonstrated in the one-step synthesis of known pharmaceuticals from com. available, simple enantiopure primary amines and achiral alcs. It was also found that the use of β-branched enantioenriched primary alcs. and achiral amines as reaction partners leads to a partial loss of stereochem. integrity in the final product, however, a systematic optimization enabled partial retention of enantiopurity and possible parameters effecting for racemization were identified.
Advanced Synthesis & Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application In Synthesis of 111-29-5.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts