Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease was written by Bertoglio, Daniele;Bard, Jonathan;Hessmann, Manuela;Liu, Longbin;Gartner, Annette;De Lombaerde, Stef;Huscher, Britta;Zajicek, Franziska;Miranda, Alan;Peters, Finn;Herrmann, Frank;Schaertl, Sabine;Vasilkovska, Tamara;Brown, Christopher J.;Johnson, Peter D.;Prime, Michael E.;Mills, Matthew R.;Van der Linden, Annemie;Mrzljak, Ladislav;Khetarpal, Vinod;Wang, Yuchuan;Marchionini, Deanna M.;Skinbjerg, Mette;Verhaeghe, Jeroen;Dominguez, Celia;Staelens, Steven;Munoz-Sanjuan, Ignacio. And the article was included in Science Translational Medicine in 2022.COA of Formula: C9H18O5S The following contents are mentioned in the article:
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathol. mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract. Whereas several therapeutic programs targeting mHTT expression have advanced to clin. evaluation, methods to visualize mHTT protein species in the living brain are lacking. Here, we demonstrate the development and characterization of a positron emission tomog. (PET) imaging radioligand with high affinity and selectivity for mHTT aggregates. This small mol. radiolabeled with 11C ([11C]CHDI-180R) allowed noninvasive monitoring of mHTT pathol. in the brain and could track region- and time-dependent suppression of mHTT in response to therapeutic interventions targeting mHTT expression in a rodent model. We further showed that in these animals, therapeutic agents that lowered mHTT in the striatum had a functional restorative effect that could be measured by preservation of striatal imaging markers, enabling a translational path to assess the functional effect of mHTT lowering. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1COA of Formula: C9H18O5S).
(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C9H18O5S
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