Phytochemical composition, antioxidant, enzyme inhibition, antimicrobial effects, and molecular docking studies of Centaurea sivasica was written by Yirtici, Umit;Ergene, Aysun;Atalar, Mehmet Nuri;Adem, Sevki. And the article was included in South African Journal of Botany in 2022.Electric Literature of C20H22O8 The following contents are mentioned in the article:
In this study, Centaurea sivasica Wageitz (Asteraceae) methanol extract was examined regarding phytochem. composition, in vitro antioxidant properties, ability to inhibit tyrosinase, α-amylase, α-glucosidase enzymes, and antimicrobial effects. Also, possible binding and interactions of phytochems. with enzymes by mol. docking were determined The extract′s phenolic amount was 21.42 mg GAE/g extract, and the extract was determined to be rich in flavonoids (19.73 mg RE/g extract). Due to the results of liquid chromatog.-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) anal., the main components of the methanol extract was scutellarin (27843.91 μg/g), quercimeritrin (3629.85 μg/g), chlorogenic acid (2519.68 μg/g) and baicalin (920.49 μg/g). The methanol extract was found to show remarkable activity in all antioxidant activity tests and had a high potential to inhibit the enzymes examined The extract was radical scavenging on (DPPH and ABTS), reducing power (FRAP and CUPRAC), phosphomolybdenum assays were measured as 2.72, 69.58, 44.78, 141.18, 109.25 mg TE/g extract, resp. Tyrosinase, α-amylase, and α-glucosidase inhibitory activities were 36.81 mg KE/g extract, 252.60 and 279.40 mg AKE/g extract, resp. Scutellarin inhibited the tyrosinase enzyme very effectively, and its effect was found as 43.32 μM or 20.38 μg/mL. The extract showed different inhibition zones (16.3, 16.0, 15.0, 15.6 mm) and MIC values (500-1000 μg/mL) on the microorganisms examined (B. cereus, S. aureus, E. coli, C. albicans). In mol. docking studies, the most abundant scutellarin in the extract was shown to affect both tyrosinase and α-glucosidase inhibition significantly. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Electric Literature of C20H22O8).
(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C20H22O8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts