Molecular chirality mediated amyloid formation on phospholipid surfaces was written by Wang, Xue;Wang, Cunli;Chu, Huiying;Qin, Haijuan;Wang, Dongdong;Xu, Feifei;Ai, Xuanjun;Quan, Chunshan;Li, Guohui;Qing, Guangyan. And the article was included in Chemical Science in 2020.Application of 923-61-5 The following contents are mentioned in the article:
One of the neuropathol. features of Alzheimer’s disease (AD) is the misfolding of amyloid-β to form amyloid aggregates, a process highly associated with biol. membranes. However, how mol. chirality affects the amyloid formation on phospholipid surfaces has seldom been reported. Here, L- and D-aspartic acid-modified 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (L-/D-Asp-DPPE) is synthesized to construct chiral phospholipid bilayers. We discover that the L-Asp-DPPE liposomes slightly inhibit the Aβ(1-40) nucleation process but cannot affect the oligomer elongation process. By contrast, the D-Asp-DPPE liposomes strongly inhibit both nucleation and elongation of the peptide. Notably, L- and D-Asp-DPPE liposomes not only have good biocompatibility but can also rescue Aβ(1-40)-aggregation induced cytotoxicity with significant chiral discrimination, in which the cell viability is higher in the presence of D-Asp-DPPE liposomes. Mechanism anal. and mol. dynamics simulation clearly demonstrate that differential electrostatic interactions of Lys16 in Aβ(1-40) with L- or D-Asp on the phospholipid contribute to the remarkable chiral discrimination. This study provides a deeper understanding of the crucial amyloidosis process from the perspective of the chiral interface and reveals that the convergence of D-amino acids with the liposomes might be a feasible route for AD prevention. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Application of 923-61-5).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 923-61-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts