The bisphenol F and bisphenol S and cardiovascular disease: results from NHANES 2013-2016 was written by Wang, Ruihua;Fei, Qiaoyuan;Liu, Shan;Weng, Xueqiong;Liang, Huanzhu;Wu, Yingying;Wen, Lin;Hao, Guang;Cao, Guangwen;Jing, Chunxia. And the article was included in Environmental Sciences Europe in 2022.Safety of 4,4′-Methylenediphenol The following contents are mentioned in the article:
Bisphenol F (BPF) and bisphenol S (BPS) have replaced bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins; however, the effects of these substitutes on the risk of cardiovascular disease (CVD), including congestive heart failure, coronary heart disease, angina pectoris, heart attack, and stroke, have not been assessed. To examine the association of urinary BPS and BPF with CVD risk in a U.S. representative U.S. population. Cross-sectional data from 1267 participants aged 20-80 years from the 2013-2016 National Health and Nutrition Examination Survey (NHANES) were analyzed. Survey-weighted multiple logistic regression was used to assess the association between BPA, BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixture effect. A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, the T3 tertile concentration of BPS increased the risk of total CVD (OR: 1.99, 95% CI 1.16-3.40). When stratified by age, we found that BPS increased the risk of CVD in the 50-80 age group (OR: 1.40, 95% CI 1.05-1.87). BPS was pos. associated with the risk of coronary heart disease, and the T3 tertile concentration of BPS increased the coronary heart disease risk by 2.22 times (95% CI 1.04-4.74). No significant association was observed between BPF and CVD. Although the BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased with increasing compound concentration Our results suggest that BPS may increase the risk of total CVD and coronary heart disease in the US population, and prospective studies are needed to confirm the results. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Safety of 4,4′-Methylenediphenol).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 4,4′-Methylenediphenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts