Influence of amphotericin B on the thermodynamic properties and surface morphology of saturated phospholipid monolayer with different polar head at the air-water interface was written by Wang, Juan;Zhu, Hao. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2021.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:
Amphotericin B is not only a widely used antifungal drug, but also a potential novel immunotherapy anticancer drug. But it has great side effects on human body due to its pore-forming activity on cell′s membrane. Some researchers have found that AmB can form pores on the phospholipid monolayer in the absence of sterol. However, the effect of different polar heads of phospholipids on the pore-forming activity of AmB on the membrane is rarely reported. In this work, the influence of amphotericin B on the thermodn. properties and surface morphol. of saturated phospholipid monolayer with different polar head at the air-water interface have been studied. The results suggested that the intermol. force between AmB and DPPC or DPPE mols. was attractive but the force between AmB and DPPG or DPPS mols. was repulsive. No matter what kind of phospholipid′s polar head, AmB can enhance the disorder of the AmB/phospholipid mixed monolayer. But at 30 mN/m, this effect of AmB from strong to weak was in the presence of PS head, PG head, PC head and PE head. And the drug can induce the phase state of the phospholipid monolayer to change from LC phase to LC-LE phase at 30 mN/m. Differently, the shape and distribution of LC phase domains in the mixed monolayer film with non-charged head group were different from that with neg. charged head group, which may be due to the intermol. force between AmB and different phospholipid. The results are helpful to understand the influence of AmB on the domains without sterols on cell membrane, to lay the foundation for the interaction between AmB and phospholipid-sterol binary model membranes in the further study and to provide a basis for understanding the interaction between AmB and liposome materials. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts