Estimation of parabens and bisphenols in maternal products and urinary concentrations in Indian pregnant women: daily intake and health risk assessment was written by Varghese, Bincy;Jala, Aishwarya;Das, Panchanan;Borkar, Roshan M.;Adela, Ramu. And the article was included in Environmental Science and Pollution Research in 2022.Synthetic Route of C13H12O2 The following contents are mentioned in the article:
The presence of parabens and bisphenols in maternal products and usage during pregnancy have raised serious concern about their possible harm to pregnant women. The concentrations of six parabens and eight bisphenols were quantified by high-performance liquid chromatog.-tandem mass spectrometry in the samples of com. available herbal-based ayurvedic maternal products and urine of healthy pregnant women from Assam, India. Me paraben (MP) and bisphenol AF (BPAF) were found to be more dominant in the maternal products, whereas MP, bisphenol A (BPA), and BPAF were dominant in urine samples of healthy pregnant women. The sum of the mean concentrations of all forms of parabens and bisphenols in maternal products were 48,308.50 ng/g and 542.42 ng/g, resp., and urine 101.33 ng/mL and 23.42 ng/mL, resp. The estimated daily intake (EDI) of total parabens and bisphenols in maternal products were 7378.02 and 19.78 ng/kg body weight/day, resp. EDI of total parabens and bisphenols from urinary concentrations were 690.12 and 111.33μg/kg body weight/day, resp. The concentrations of Bu (BP) and heptyl (HP) parabens have a significant pos. correlation with birth weight The hazard quotient (HQ) value of MP, EP, and BPA was less than 1, and margin of exposure (MOE) identified potential risk associated with Pr paraben. Results from Monte-Carlo risk assessment anal. did not exceed the acceptable daily intake (ADI). Our results showed that higher concentrations of parabens and bisphenols are present in maternal products and the urine of healthy pregnant women. Hence maternal products containing bisphenols and parabens should be used cautiously during pregnancy to avoid maternal and fetal complications. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C13H12O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts