Associations of bisphenol exposure with the risk of gestational diabetes mellitus: a nested case-control study in Guangxi, China was written by Tang, Peng;Liang, Jun;Liao, Qian;Huang, Huishen;Guo, Xiaojing;Lin, Mengrui;Liu, Bihu;Wei, Bincai;Zeng, Xiaoyun;Liu, Shun;Huang, Dongping;Qiu, Xiaoqiang. And the article was included in Environmental Science and Pollution Research.Synthetic Route of C13H12O2 The following contents are mentioned in the article:
A growing number of epidemiol. studies have estimated the associations between endocrine-disrupting chems. and gestational diabetes mellitus (GDM). However, reports on the association between bisphenol A (BPA) substitutes and GDM are limited. This investigation aimed to explore the associations of maternal serum BPA, bisphenol B (BPB), bisphenol F (BPF), bisphenol S (BPS), and tetrabromobisphenol A (TBBPA) with the risk of GDM. A nested case-control study was performed among 500 pregnant women. In conditional logistic regression models, the OR for BPS was significantly increased in the medium exposure groups (OR = 1.77; 95% CI: 1.01, 3.13) compared with the reference group, while BPA (OR: 0.38, 95%CI: 0.29, 0.50) and TBBPA (OR: 0.67, 95%CI: 0.54, 0.85) were neg. associated with the risk of GDM. In the Bayesian kernel machine regression (BKMR) anal., the joint effect of bisphenols was pos. associated with the risk of GDM. BPS showed pos. relationship, while BPA and TBBPA showed neg. relationship, resp. The quantile g-computation revealed a statistically significant and neg. joint effect of the five bisphenols on the risk of GDM (OR: 0.57; 95% CI: 0.46, 0.72) with BPA (70.2%), TBBPA (21.3%), and BPB (8.5%) had pos. contribution to the overall effect. These findings suggested that BPS had a pos. effect on the risk of GDM, while BPA and TBBPA had neg. effect on the risk of GDM. Moreover, exposure to the mixture of the five bisphenols was neg. associated with the risk of GDM. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Synthetic Route of C13H12O2
Referemce:
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Alcohols – Chemistry LibreTexts