Network pharmacology combined with GEO database identifying the mechanisms and molecular targets of Polygoni Cuspidati Rhizoma on Peri-implants was written by Shan, Chao;Ji, Xiaowei;Wu, Zeyu;Zhao, Jin. And the article was included in Scientific Reports in 2022.Reference of 27208-80-6 The following contents are mentioned in the article:
Peri-implants is a chronic disease leads to the bone resorption and loss of implants. Polygoni Cuspidati Rhizoma (PCRER), a traditional Chinese herbal has been used to treat diseases of bone metabolism However, its mechanism of anti-bone absorption still remains unknown. We aimed to identify its mol. target and the mechanism involved in PCRER potential treatment theory to Peri-implants by network pharmacol. The active ingredients of PCRER and potential disease-related targets were retrieved from TCMSP, Swiss Target Prediction, SEA databases and then combined with the Peri-implants disease differential genes obtained in the GEO microarray database. The crossed genes were used to protein-protein interaction (PPI) construction and Gene Ontol. (GO) and KEGG enrichment anal. Using STRING database and Cytoscape plug-in to build protein interaction network and screen the hub genes and verified through mol. docking by AutoDock vina software. A total of 13 active compounds and 90 cross targets of PCRER were selected for anal. The GO and KEGG enrichment anal. indicated that the anti-Peri-implants targets of PCRER mainly play a role in the response in IL-17 signaling, Calcium signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway among others. And CytoHubba screened ten hub genes (MMP9, IL6, MPO, IL1B, SELL, IFNG, CXCL8, CXCL2, PTPRC, PECAM1). Finally, the mol. docking results indicated the good binding ability with active compounds and hub genes. PCRERs core components are expected to be effective drugs to treat Peri-implants by anti-inflammation, promotes bone metabolism Our study provides new thoughts into the development of natural medicine for the prevention and treatment of Peri-implants. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Reference of 27208-80-6).
(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 27208-80-6
Referemce:
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