Synthesis and Antifungal Activity of Novel Tetrahydrogeranyl Quaternary Ammonium Salts was written by Peng, Yun;Chang, Jiayu;Xiao, Zhuangquan;Huang, Jiazong;Xu, Ting;Chen, Shangxing;Fan, Guorong;Liao, Shengliao;Wang, Zongde;Luo, Hai. And the article was included in Natural Product Communications in 2022.COA of Formula: C10H22O The following contents are mentioned in the article:
Due to the excessive use of antifungal agents, drug resistance and ecol. problems are increasing. Some antifungal agents are difficult to degrade and have high toxicity and several side effects. In this study, 15 novel tetrahydrogeranyl quaternary ammonium salts (8a-8o) were synthesized from the natural compound citral. The structures of the quaternary ammonium salts were characterized by Fourier transform IR, proton NMR, carbon-13 NMR spectroscopy, and mass spectrometry, and the antifungal activities of these compounds at a concentration of 0.25 mg/mL against 10 plant pathogenic fungi were tested. The results showed that compound 8i had the best antifungal activity, and its inhibition rates against Rhizoctonia solani, Phytophthora parasitica var. nicotianae, Sphaeropsis sapinea, Fusarium oxysporum f. sp. niveum, and Poria vaporaria reached 100%. For Fusarium verticillioides, the inhibition rate of compound 8i was 93.28%, which was higher than that of chlorothalonil. In addition, it was found that the inhibition rates of compounds with N,N-di-Pr group (8l, 8m) against R solani, F oxysporum f. sp. niveum, S sapinea, P parasitica var. nicotianae, F verticillioides, Colletotrichum acutatum, and Coriolus versicolor were higher than compounds with N,N-di-Et and N,N-di-Me groups (8a, 8b, 8j, 8k). The inhibition rates of compounds with morpholine groups (8n, 8o) were generally low. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8COA of Formula: C10H22O).
3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C10H22O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts