Glyphaeaside C-enriched extract of Glyphaea brevis restored the antioxidant and reproductive integrity of 1,4-Dinitrobenzene-intoxicated rats was written by Olugbodi, Janet Olayemi;Olaleye, Mary Tolulope;Mostafa-Hedeab, Gomaa;Alqarni, Mohammed;Ilesanmi, Omotayo Babatunde;Batiha, Gaber El-Saber;Akinmoladun, Afolabi Clement. And the article was included in Biomedicine & Pharmacotherapy in 2022.Electric Literature of C30H26O12 The following contents are mentioned in the article:
This study assessed the fertility potential of methanol leaf extract of Glyphaea brevis (MGB) in rats exposed to 1,4-Dinitrobenzene (DNB), an environmental reprotoxicant. Male Wistar rats were orally exposed to 50 mg/kg DNB and administered 750 mg/kg MGB, 1500 mg/kg MGB or 300 mg/kg vitamin E for 21 days after 48 h of DNB exposure. Determination of serum reproductive hormone levels by enzyme-linked immunosorbent assays, evaluation of hematol. profile, computer-assisted sperm analyses (CASA) of sperm kinematics and morphol., assessment of testicular and spermatozoan antioxidant systems, and histopathol. evaluation of reproductive tissues were performed. HPLC-DAD anal. identify Glyphaeaside C as the major component of the extract In rats toxified with 50 mg/kg DNB, testicular and epididymal weights, serum levels of LH, testosterone and FSH, and packed cell volume, Hb concentration, and white blood cell counts were decreased. There was altered sperm kinematics which reflected in increased sperm abnormalities. Treatment with the Glyphaeaside C -enriched MGB counteracted all DNB-induced changes and corrected DNB-induced aberrations in kinematic endpoints. Also, testicular and epididymal antioxidant systems were disrupted and there was damage to tissue histoarchitecture. Furthermore, our mol. docking study revealed that Glyphaeaside-C exhibited high binding affinities to the binding pocket of some free radical generating enzymes. Conclusively, the results indicated that Glyphaeaside C-enriched extract of Glyphaea brevis leaf enhanced the quality of semen and improved the functional capabilities of spermatozoa following exposure of rats to DNB which could translate to enhanced fertility. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8Electric Literature of C30H26O12).
(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C30H26O12
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts