Mixtures modeling identifies heavy metals and pyrethroid insecticide metabolites associated with obesity was written by Nguyen, Hai Duc;Oh, Hojin;Jo, Won Hee;Hoang, Ngoc Hong Minh;Kim, Min-Sun. And the article was included in Environmental Science and Pollution Research in 2022.Name: 4,4′-Methylenediphenol The following contents are mentioned in the article:
We aim to examine the association between chem. mixtures and obesity. Blood and urinary levels of tween-six chems. were measured in adults who participated in the KoNEHS. We identified the associations of chems. with obesity using linear regression models. Weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) were conducted as secondary analyses. Of the 3,692 participants included in the anal., 18.0% had obesity. In the logistic regression model, mercury (Hg), lead (Pb), and 3PBA levels were associated with obesity, and significant trends were observed for these chem. tertiles (p < 0.001). Hg, Pb, and 3PBA levels were also associated with BMI. The WQS index was significantly associated with both obesity (OR = 2.15, 95% CI: 2.11-2.20) and BMI (β = 0.39, 95% CI: 0.37-0.51). The qgcomp index also found a significant association between chems. and both obesity (OR = 1.70, 95% CI: 1.56-1.85) and BMI (β = 0.40, 95% CI: 0.39-0.41). Hg, Pb, and 3PBA were the most heavily weighed chems. in these models. In BKMR anal., the overall effect of the mixture was significantly associated with obesity. Hg, Pb, and 3PBA showed pos. trends and were observed as the most important factors associated with obesity. Given increasing exposure to chems., there is a need to investigate the associations between chem. exposures, either sep. or together, and incident obesity risk factors in well-characterized cohorts of different populations, and to identify potential approaches to chem. exposure prevention. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Name: 4,4′-Methylenediphenol).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 4,4′-Methylenediphenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts