Bisphenol S promotes the progression of prostate cancer by regulating the expression of COL1A1 and COL1A2 was written by Liu, Shengdi;He, Bin;Li, Hua. And the article was included in Toxicology in 2022.Reference of 620-92-8 The following contents are mentioned in the article:
In recent decades, Bisphenol S (BPS), which was once thought to be an alternative for Bisphenol A (BPA) has been extensively used in personal care products, paper products, and food. However, there is an unclear association between bisphenol and tumors. Therefore, clarifying this relationship is critical for disease prevention and treatment. This work found a novel method that predicts a correlation between bisphenol interactive genes and tumors. First, the transcriptome profile and interactive genes of bisphenol were obtained from The Cancer Genome Atlas and Genotype-Tissue Expression, Comparative Toxicol. Genomics, and PharmMapper databases. Gene Ontol. and Kyoto Encyclopedia of Genes and Genomes anal. revealed that interactive genes are primarily enriched in prostate cancer. Gene targeted prediction and gene set variation anal. confirmed that bisphenol exerts potential effects on prostate cancer. The operating characteristic curves and survival anal. uncovered the role of COL1A1 and COL1A2 in predicting the prognosis of prostate cancer. Cell counting kit-8 assay revealed that BPS-treated cells could remarkably promote cell proliferation capacity in both PC-3 and LNCap cells. In addition, wound healing and transwell assays demonstrated that BPS-treated cells could significantly promote the cell invasion capacity of prostate cells. Notably, two key genes, i.e., COL1A1 and COL1A2 were significantly upregulated with BPS-treated PC-3 and LNCap cells. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 620-92-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts