Synthesis and Characterization of Partially and Fully Saturated Menaquinone Derivatives was written by Koehn, Jordan T.;Crick, Dean C.;Crans, Debbie C.. And the article was included in ACS Omega in 2018.COA of Formula: C10H22O The following contents are mentioned in the article:
Menaquinones (MK) contain both a redox active quinone moiety and a hydrophobic repeating isoprenyl side-chain of varying length and degrees of saturation This characteristic structure allows MKs to play a key role in the respiratory electron transport system of some prokaryotes by shuttling electrons and protons between membrane-bound protein complexes, which act as electron acceptors and donors. Hydrophobic MK mols. with partially and fully saturated isoprenyl side-chains are found in a wide range of eubacteria and Archaea and the structural variations of the MK analogs are evolutionarily conserved but poorly understood. For example, Mycobacterium tuberculosis, the causative agent of tuberculosis, uses predominantly MK-9(II-H2) (saturated at the second isoprene unit) as its electron carrier and depends on the synthesis of MK-9(II-H2) for survival in host macrophages. Thus, MKs with partially saturated isoprenyl side-chains may represent a novel virulence factor. Naturally occurring longer MKs are very hydrophobic, while MK analogs that have a truncated (i.e., 1-3 isoprenes) isoprenyl side-chain are less hydrophobic. This improves their solubility in aqueous solutions allowing rigorous study of their structure and biol. activity. We present the synthesis and characterization of two partially saturated MK analogs, MK-2(II-H2) I and MK-3(II-H2) II, and two novel fully saturated MK derivatives, MK-2(I,II-H4) III and MK-3(I,II,III-H6) IV. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8COA of Formula: C10H22O).
3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C10H22O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts