The nanoscopic molecular pathway through human skin was written by Iachina, I.;Antonescu, I. E.;Dreier, J.;Soerensen, J. A.;Brewer, J. R.. And the article was included in Biochimica et Biophysica Acta, General Subjects in 2019.SDS of cas: 923-61-5 The following contents are mentioned in the article:
Knowledge regarding the barrier properties of human skin is important for understanding skin pathol., developing of transdermal drug delivery systems and computational skin absorption models; however, the mol. pathways through human skin remains to be fully investigated on a nanoscopic level. In particular the nanoscopic pathway of mols. passing the intercellular lipid bilayers separating the corneocytes in the stratum corneum (SC) is not fully elucidated. Using stimulated emission depletion microscopy (STED) and Forster resonance energy transfer (FRET) the mol. pathways through the SC, the main barrier of the skin, are determined for lipophilic and water-soluble mols. at a nanoscopic resolution Using STED and confocal microscopy, water-soluble dyes, were observed to be present in both the corneocytes and in the intercellular lipid matrix, whereas the lipophilic dyes were predominately in the intercellular lipid bilayers. FRET was observed in the SC between the lipophilic and water-soluble dyes, the existence of a min. possible distance between acceptor and donor mols. of 4.0 ± 0.1 nm was found. The results indicate that lipophilic mols. penetrate the stratum corneum via the intercellular lipids bilayers separating the corneocytes in the SC, while the more water-soluble mols. penetrate the stratum corneum via the transcellular route through the corneocytes and intercellular lipid bilayers via the polar head groups of lipid mols. in the bilayers. Knowledge of the nanoscopic mol. pathways through human skin will help understand the skin barrier function and will be of use for computational skin absorption models and transdermal drug delivery strategies. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5SDS of cas: 923-61-5).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 923-61-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts