Assessment of antidiabetic potential and phytochemical profiling of Rhazya stricta root extracts was written by Mahmood, Rashid;Kayani, Waqas Khan;Ahmed, Tanveer;Malik, Farnaz;Hussain, Shahzad;Ashfaq, Muhammad;Ali, Hussain;Rubnawaz, Samina;Green, Brian D.;Calderwood, Danielle;Kenny, Owen;Rivera, Gerardo A.;Mirza, Bushra;Rasheed, Faiza. And the article was included in BMC Complementary Medicine and Therapies in 2020.Computed Properties of C9H20O2 The following contents are mentioned in the article:
Diabetes mellitus is a chronic disease characterized by hyperglycemia that may occur due to genetic, environmental or lifestyle factors. Natural remedies have been used to treat diabetes since long and many antidiabetic compounds of varied efficacies have been isolated from medicinal plants. Rhazya stricta has been used for decades for the treatment of diabetes mellitus and associated ailments. Considering the folkloric use of R. stricta against diabetes, it was aimed to investigate the effectiveness of its root extracts against diabetes through in vitro assays and in vivo studies using animal model along with phytochem. profiling through GCMS. Various fractions of Rhazya stricta obtained through column chromatog. were evaluated for a variety of assays including α-glucosidase, Dipeptidyl peptidase-IV (DPP-IV), β-secretase and Glucagon-like peptide-1 (GLP-1) secretion studies. For the in vivo studies the alloxan-induced diabetic mice were treated with root extracts and blood glucose levels, HbA1C, and other biochem. markers along with the histol. study of the liver were done. The phytochem. identification was performed using an Agilent 7890B GC coupled to a 7010 Triple Quadrupole (MS/MS) system. GraphPad Prism software version 5.01 was used for statistical anal. Majority of the extract fractions showed excellent results against diabetes by inhibiting enzymes DPP-IV (Up to 61%) and β-secretase (Up to 83%) with IC50s 979 μg/mL and 169 μg/mL resp. with increase in the GLP1 secretion. The results of in vivo studies indicated a marked reduction in blood glucose and HbA1c levels along with pos. effects on other parameters like lipid profile, liver functions and renal functions of extract-treated mice as compared to control. The histol. examination of the liver demonstrated hepatoprotective effects against diabetes led changes and various classes of phytochems. were also identified through GCMS in different fractions. The results revealed strong antidiabetic activity of R. stricta root with the potential to protect body organs against diabetic changes. Moreover, a variety of phytochems. has also been identified through GCMS that might be responsible for the antidiabetic potential of Rhazya stricta root. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Computed Properties of C9H20O2).
2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C9H20O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts