Schiff base Sn(IV) complexes as cytotoxic agents: Synthesis, structure, isosteric and bioisosteric replacement was written by Galvan-Hidalgo, Jose M.;Ramirez-Apan, Teresa;Nieto-Camacho, Antonio;Hernandez-Ortega, Simon;Gomez, Elizabeth. And the article was included in Journal of Organometallic Chemistry in 2017.Related Products of 65-22-5 The following contents are mentioned in the article:
The preparation and characterization of two series of organotin(IV) 4-pyridinecarbaldimine Schiff base complexes I (R1 = Cy, CH2SiMe3; R = H, F, Cl, Me, MeO, NO2, tBu) are reported, each series differing in the nature of the substituent bonded to the tin atom (cyclohexyl or bis(trimethyl)silylmethyl). The isosteric and bioisosteric approach was used as the strategy of mol. design. The ligand was 5-hydroxymethyl-4-[(2-hydroxyphenyl)iminomethyl]-2-methylpyridin-3-ol substituted at position 4 by Me, halogeno (F, Cl), methoxy, nitro and tert-butyl; the synthesis of the organotin(IV) complexes was performed by a multi-component strategy in reasonable to high yields depending on the nature of the ligand. All new complexes were fully characterized by IR, MS, X-ray determinations and NMR (1H, 13C, 119Sn). Crystallog. data of complexes showed the geometries adopted around the metal tin center varied between square pyramidal in 2c and a trigonal bipyramidal in 3b–3d with the alkyl groups in the trigonal plane and the two oxygen atoms in the equatorial plane. Addnl., the in vitro cytotoxicity tests of the complexes towards six types of human cancerous cell lines U-251 (glioblastoma), K-562 (chronic myelogenous leukemia), HCT-15 (human colorectal), MCF-7 (human breast), MDA-MB-231 (human breast) and SKLU-1 (non-small cell lung) showed the superior activity of the organotin complexes compared to the corresponding cisplatin used as pos. control. The complexes containing fluorine exhibited excellent IC50 data indicating that both the bioisosteric replacement and the cyclohexyl ring bonded to the tin atom increased the potency of the cytotoxic activity towards the cancer cell lines tested. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts