Structural elucidation upon binding of antimicrobial peptides into binary mixed lipid monolayers mimicking bacterial membranes was written by Ciumac, Daniela;Gong, Haoning;Campbell, Richard A.;Campana, Mario;Xu, Hai;Lu, Jian R.. And the article was included in Journal of Colloid and Interface Science in 2021.Related Products of 923-61-5 The following contents are mentioned in the article:
Antimicrobial peptides (AMPs) kill microorganisms by causing structural damage to bacterial membranes. Different microorganisms often require a different type and concentration of an AMP to achieve full microbial killing. We hypothesise that the difference is caused by different membrane structure and composition Given the complexities of bacterial membranes, we have used monolayers of the binary DPPG/TMCL mixture to mimic the cytoplasmic membrane of Gram-pos. bacteria and the binary DPPG/DPPE mixture to mimic the cytoplasmic membrane of Gram-neg. bacteria, where DPPG, TMCL and DPPE stand for 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol), 1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-sn-glycerol, and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, resp. A Langmuir trough was specially designed to control the spread lipid monolayers and facilitate neutron reflectivity measurements. Surface pressure-area isotherm anal. revealed that all binary lipid systems mix non-ideally, but mixing is thermodynamically favored. An increase in the surface pressure encourages demixing, resulting in phase separation and formation of clusters. Neutron reflectivity measurements were undertaken to study the binding of an antimicrobial peptide G(IIKK)4-I-NH2 (G4) to the binary DPPG/TMCL and DPPG/DPPE monolayer mixtures at the molar ratios of 6/4 and 3/7, resp. The results revealed stronger binding and penetration of G4 to the DPPG/TMCL monolayer, indicating greater affinity of the antimicrobial peptide due to the electrostatic interaction and more extensive penetration into the more loosely packed lipid film. This work helps explain how AMPs attack different bacterial membranes, and the results are discussed in the context of other lipid models and antibacterial studies. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Related Products of 923-61-5).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 923-61-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts