3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 65-22-5
Catecholase activity, DNA binding and cytotoxicity studies of a Cu(II) complex of a pyridoxal Schiff base: synthesis, x-ray crystal structure, spectroscopic, electrochemical and theoretical studies was written by Adak, Piyali;Ghosh, Bipinbihari;Bauza, Antonio;Frontera, Antonio;Blake, Alexander J.;Corbella, Montserrat;Das Mukhopadhyay, Chitrangada;Chattopadhyay, Shyamal Kumar. And the article was included in RSC Advances in 2016.Reference of 65-22-5 The following contents are mentioned in the article:
A binuclear Cu(II) complex [Cu(L1Hpy)Cl]2(ClO4)2 (1), where L1H2 is a new tridentate ligand, formed by condensation of 2-aminomethylpyridine and pyridoxal (one of the forms of vitamin B6), was synthesized. X-ray crystal structure determination shows that in this complex two Cu(II) ions are interconnected by complementary hydroxymethyl bridges of the two pyridoxal moieties, which is a very rare example in the literature. However, with a Cu···Cu separation of 6.574(1) Å and Cu-O(H)CH2– distance of 2.289 Å, the bridge is very weak, and DFT calculations, as well as ESI-MS data and solution spectral studies indicate that in a MeOH solution the complex exists predominantly as a mixture of monomers [Cu(L1Hpy)Cl]+ and [Cu(L1Hpy)(MeOH)]2+ with the former being the predominant form. The DFT calculations as well as EPR spectra suggest that the SOMO is a metal dx2-y2 orbital. The complex shows highly efficient catecholase activity with kcat = 3·46 × 105 h-1 and kcat/KM = 1.00 × 108 M-1 h-1, which are the best values reported in the literature, so far, for catecholase mimicking model complexes. DFT calculations show that the reduction of the Cu(II)/Cu(I) by the coordinated catechol and the resultant structural changes is the rate determining step in the catalytic cycle. The complex also binds DNA quite strongly with a binding constant of ∼105 M-1. DFT calculations suggest that the most probable binding mode of the complex is intercalation of the pyridine ring of the complex between two adenine or adenine and cytosine base pairs. The complex shows low cytotoxicity towards HCT and HeLa cells, though cytotoxicity towards the latter cell line is much higher than the former. Also the complex can be used as a fluorescence probe for imaging HCT cells. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts