In 2019,Organic Letters included an article by Yi, Jun; Badir, Shorouk O.; Kammer, Lisa Marie; Ribagorda, Maria; Molander, Gary A.. Application In Synthesis of trans-4-Aminocyclohexanol. The article was titled 《Deaminative Reductive Arylation Enabled by Nickel/Photoredox Dual Catalysis》. The information in the text is summarized as follows:
Described is a cross-electrophilic, deaminative coupling strategy harnessing Katritzky salts as a new species of electrophile in Ni/photoredox dual catalytic reductive cross-coupling reactions. Distinguishing features of this arylation protocol include its mild reaction conditions, high chemoselectivity, and adaptability to a variety of complex substrates [i.e., pyridinium salts derived from amines and partners derived from (hetero)aryl bromides]. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Application In Synthesis of trans-4-Aminocyclohexanol)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application In Synthesis of trans-4-Aminocyclohexanol
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