In 2013,Wang, Jie; Zhu, Xiao-hua; Chen, Guo-hua published 《Process improvement on the synthesis of 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride》.Hecheng Huaxue published the findings.Formula: C3H8ClNO The information in the text is summarized as follows:
A key intermediate of Tebipenem pivoxil, 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, was synthesized from benzylamine by N-alkylation, cyclization, catalytic hydrogenation, N-protection, mesylation, SN2 substitution, hydrolysis, and condensation. The overall yield was 40%. The structure was confirmed by 1H NMR, IR and MS. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Formula: C3H8ClNO)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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