《Palladium-Catalyzed Desulfurative Amide Formation from Thioureas and Arylboronic Acids》 was published in ChemCatChem in 2020. These research results belong to Su, Jianke; Li, Wendong; Li, Xin; Xu, Jian; Song, Qiuling. Formula: C12H17BO2 The article mentions the following:
Herein, the Pd-catalyzed desulfurative amide formation involved Suzuki-Miyaura coupling reaction, notably the Pd complex was generated in situ from thioureas and Ag salt and Pd catalyst were discovered. Silver salt was essential for the construction of this type of carbenes from available and stable thioureas R1R2NC(S)NR3R4 (R1 = Me, 4-fluorophenyl, 4-chlorophenyl, phenyl; R2 = Me; R3 = Me; R4 = Me, 4-fluorophenyl, 4-chlorophenyl, phenyl; R1R2 = -(CH2)5-, -(CH2)4-, -(CH2)2O(CH2)2-; R3R4 = -(CH2)5-, -(CH2)4-, -(CH2)2O(CH2)2-) and well participated in the catalytic cycle. A method for the synthesis of arylamides R5C(O)NR3R4 (R5 = acetyl, Ph, naphthalen-2-yl, 4-(benzenesulfonyl)morpholine, etc.) from arylboronic acids R5B(OH)2, which greatly enriched the application of thioureas chem. and expanded the application of the Suzuki-Miyaura coupling was developed. The experimental process involved the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Formula: C12H17BO2)
4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Formula: C12H17BO2
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