In 2011,Shi, Ying; Zhang, Ya-ran; Di, Hui-feng; Jia, Ming; Zhang, Zhi-bao published 《Synthesis of 3-mercapto-1-(1,3-thiazolin-2-yl)azetidine hydrochloride》.Huaxue Shiji published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:
3-Mercapto-1-(1,3-thiazolin-2-yl) azetidine hydrochloride has been synthesized from 2-mercaptothiazoline, through methylation, SN2 nucleophilic substitution with 3-hydroxyazetidine hydrochloride, activation of the hydroxyl group with methanesulfonyl chloride, SN2 nucleophilic substitution of the resultant mesylate with potassium thioacetate, and basic hydrolysis. The total yield was 51.6%, and purity of product was 98.5%. The method features mild conditions, easy manipulation, high purity and suitability for industrialization.Azetidin-3-ol hydrochloride(cas: 18621-18-6Category: alcohols-buliding-blocks) was used in this study.
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Category: alcohols-buliding-blocks Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts