Shen, Haigen; Xiao, Hawen; Zhu, Lin; Li, Chaozhong published an article on January 31 ,2020. The article was titled 《Copper-Catalyzed Radical Bis(trifluoromethylation) of Alkynes and 1,3-Enynes》, and you may find the article in Synlett.Product Details of 20880-92-6 The information in the text is summarized as follows:
The copper-catalyzed radical bis(trifluoromethylation) of alkynes ArCCH [Ar = 4-tert-butylphenyl, phenanthren-9-yl, 2-methyl-1,3-benzothiazol-6-yl, [4-([[(1R,2S,5R)-5-methyl-2-(propan-2- yl)cyclohexyl]oxy]carbonyl)phenyl], etc.] and 1,3-enynes R1CCC(=CH2)R2 (R1 = 4-bromophenyl, 9-oxo-9H-fluoren-2-yl, 3-[(benzenesulfonyl)oxy]propyl, etc.; R2 = H, Me) is described. With Cu(CH3CN)4BF4as the catalyst, the reaction of arylalkynes with Togni reagent II and (bpy)Zn(CF3)2 at room temperature affords the corresponding 1,2-bis(trifluoromethylated) alkenes ArC(CF3)=CHCF3 in good yields with excellent E-stereoselectivity. Under similar conditions, the reaction of 1,3-enynes provides the corresponding 1,4-bis(trifluoromethylated) allenes R1C(CF3)=C=C(CH2CF3)R2 exclusively in satisfactory yields. The protocol exhibits broad substrate scope and excellent functional group compatibility. In the experiment, the researchers used many compounds, for example, ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)
((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II). And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6
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