Li, Zi; Ren, Xiangzhu; Sun, Peng; Ding, Hao; Li, Shumu; Zhao, Yilin; Zhang, Ke published an article in 2021. The article was titled 《Protecting-Group-Free Iterative Exponential Growth Method for Synthesizing Sequence-Defined Polymers》, and you may find the article in ACS Macro Letters.Electric Literature of C7H6O3 The information in the text is summarized as follows:
As a main synthetic strategy for monodisperse sequence-defined polymers, the known iterative exponential growth (IEG) methods were all developed on protecting-group chem., where the addnl. deprotection reactions increased their synthetic steps and decreased their atom economy. In this study, we developed a protecting-group-free IEG method for the formation of sequence-defined polymers by combining three orthogonal click reactions of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), sulfur-fluoride exchange reaction (SuFEx), and Ugi four-component reaction (Ugi-4CR). In this approach, oligomer synthesis began with three parallel CuAAC, SuFEx, and Ugi-4CR couplings among three monomers each with two orthogonal clickable end groups. By iteratively applying parallel CuAAC, SuFEx, and Ugi-4CR to couple three resultant oligomers, each having two orthogonal clickable terminals, this approach could exponentially grow three different sequence-defined polymers simultaneously with high efficiency, requiring no protecting-group chem. Addnl., each Ugi-4CR coupling reaction could introduce two external side groups to provide the mol. variation and side-chain functionalization for the resultant sequence-defined polymers. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts