《Protein crystal occurrence domains in selective protein crystallisation for bio-separation》 was written by Li, Xiaoyu; Chen, Wenqian; Yang, Huaiyu; Yang, Zhongqiang; Heng, Jerry Y. Y.. Application of 6381-59-5 And the article was included in CrystEngComm in 2020. The article conveys some information:
Bio-separation is a key bottleneck in the manufacture of biopharmaceuticals. In this work, we report exptl. evidence of direct selective protein crystallization from a binary protein mixture solution Lysozyme-thaumatin mixtures with a wide protein composition range (0-100 mg mL-1, resp.) were tested under the same crystallization cocktail conditions using the hanging-drop vapor-diffusion (HDVD) crystallization method. This work demonstrates the selectivity of crystallization from a model binary protein mixture and four crystal occurrence domains were determined as the operation windows of selective crystallization of the target protein: (1) an unsaturated region with no crystal formation, (2 & 3) target regions with only a single type of protein crystals (lysozyme crystals only or thaumatin crystals only) and (4) a mixture region which have a mixture of both types of protein. This study demonstrates that protein crystallization is not only applicable to high-purity protein solutions and emphasizes the vital impacts of the presence of protein impurities in the process of target protein crystallization The study concludes that protein crystallization is a feasible approach to sep. a target protein from a complex mixture environment which can be achieved by manipulating the crystallization operation conditions such as mixture composition, precipitant concentration, and operation time. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)
Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.
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