In 2022,Ksila, Mohamed; Vejux, Anne; Prost-Camus, Emmanuelle; Durand, Philippe; Ghzaiel, Imen; Nury, Thomas; Duprey, Dorian; Meziane, Smail; Masmoudi-Kouki, Olfa; Latruffe, Norbert; Ghrairi, Taoufik; Prost, Michel; Lizard, Gerard; Vervandier-Fasseur, Dominique published an article in Molecules. The title of the article was 《Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells》.Related Products of 26153-38-8 The author mentioned the following in the article:
Trans-resveratrol is a natural polyphenol showing numerous biol. properties, especially anti-tumoral and antioxidant activity. Among numerous resveratrol derivatives, aza-stilbenes, which bear an imine bound, show interesting biol. activities. In the present study, we synthesized a series of imine analogs of trans-resveratrol (seven aza-stilbenes) following an easy and low-cost procedure of green chem. The toxicity of synthesized aza-stilbenes, which is currently unknown, was evaluated on murine neuronal N2a cells, comparatively to trans-resveratrol, by considering: cell d. evaluated by staining with sulforhodamine 101; esterase activity, which is a criteria of cell viability, by staining with fluorescein diacetate; and transmembrane mitochondrial potential, which is known to decrease during cell death, by staining with DiOC6(3) using flow cytometry. In addition, the antioxidant activity was quantified with the KRL (Kit Radicaux Libres) assay, the DPPH (2,2- diphenyl-1-picrylhydrazyl radical) assay and the FRAP (ferric reducing antioxidant power) assay. The PAOT (Pouvoir Antioxidant Total) score was also used. The aza-stilbenes provide different cytotoxic and antioxidant activities, which are either higher or lower than those of trans-resveratrol. Based on their cytotoxic and antioxidant characteristics, all synthesized aza-stilbenes are distinguished from trans-resveratrol. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Related Products of 26153-38-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts