Computed Properties of C3H8ClNOIn 2019 ,《tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity》 was published in RSC Advances. The article was written by Kotb, Ahmed; Abutaleb, Nader S.; Hagras, Mohamed; Bayoumi, Ashraf; Moustafa, Mahmoud M.; Ghiaty, Adel; Seleem, Mohamed N.; Mayhoub, Abdelrahman S.. The article contains the following contents:
The structure-activity and structure-kinetic relationships of a new tert-butylphenylthiazole series with oxadiazole linkers were conducted with the objective of obtaining a new orally available antibacterial compounds Twenty-two new compounds were prepared, purified and identified. Their activity against methicillin-resistant Staphylococcus aureus were examined Compound 20 with 3-hydroxyazetidine as a nitrogenous side chain showed promising activity against twenty-four clin. isolates, including vancomycin-resistant staphylococcal and enterococcal species with MIC values ranging from 4-8 μg mL-1. Addnl. advantages of this compound include an ability to eradicate staphylococcal biofilm mass in a dose-dependent manner as well as high metabolic stability after an oral dose of 25 mg kg-1 with a biol. half-life that exceeds 5 h and a plasma concentration (Cmax) that exceeds the MIC values. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO) was used in this study.
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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