In 2019,ChemBioChem included an article by Kabiri, Yoones; Angelin, Alessandro; Ahmed, Ishtiaq; Mutlu, Hatice; Bauer, Jens; Niemeyer, Christof M.; Zandbergen, Henny; Dekker, Cees. HPLC of Formula: 4048-33-3. The article was titled 《Intercalating Electron Dyes for TEM Visualization of DNA at the Single-Molecule Level》. The information in the text is summarized as follows:
Staining compounds containing heavy elements (electron dyes) can facilitate the visualization of DNA and related biomols. by using TEM. However, research into the synthesis and utilization of alternative electron dyes has been limited. Here, we report the synthesis of a novel DNA intercalator mol., bis-acridine uranyl (BAU). NMR spectroscopy and MS confirmed the validity of the synthetic strategy and gel electrophoresis verified the binding of BAU to DNA. For TEM imaging of DNA, two-dimensional DNA origami nanostructures were used as a robust microscopy test object. By using scanning transmission electron microscopy (STEM) imaging, which is favored over conventional wide-field TEM for improved contrast, and therefore, quant. image anal., it is found that the synthesized BAU intercalator can render DNA visible, even at the single-mol. scale. For comparison, other staining compounds with a purported affinity towards DNA, such as dichloroplatinum, cisplatin, osmium tetroxide, and uranyl acetate, have been evaluated. The STEM contrast is discussed in terms of the DNA-dye association constants, number of dye mols. bound per base pair, and the electron-scattering capacity of the metal-containing ligands. These findings pave the way for the future development of electron dyes with specific DNA-binding motifs for high-resolution TEM imaging. In addition to this study using 6-Aminohexan-1-ol, there are many other studies that have used 6-Aminohexan-1-ol(cas: 4048-33-3HPLC of Formula: 4048-33-3) was used in this study.
6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.HPLC of Formula: 4048-33-3
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