《Efficient access to 3,5-disubstituted 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidines involving SNAr and Suzuki cross-coupling reactions》 was written by Jismy, Badr; Tikad, Abdellatif; Akssira, Mohamed; Guillaumet, Gerald; Abarbri, Mohamed. SDS of cas: 27489-62-9 And the article was included in Molecules in 2020. The article conveys some information:
An efficient and original synthesis of various 3,5-disubstituted 7-(trifluoromethyl)pyrazolo [1,5-a]pyrimidines was reported. A library of compounds diversely substituted in C-3 and C-5 positions was easily prepared from a common starting material, 3-bromo-7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidin-5-one. In C-5 position, a SNAr type reaction was achieved by first activating the C-O bond of the lactam function with PyBroP (Bromotripyrrolidinophosphonium hexafluorophosphate), followed by the addition of amine or thiol giving monosubstituted derivatives, whereas in C-3 position, arylation was performed via Suzuki-Miyaura cross-coupling using the com. available aromatic and heteroaromatic boronic acids. Moreover, trifluoromethylated analogs of potent Pim1 kinase inhibitors were designed following this concise synthetic methodol. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9SDS of cas: 27489-62-9)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 27489-62-9
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