Jahan, Khorshada; Khan, Kaif Rashid; Akhter, Kawsari; Romman, Umme Kulsum Rowzatur; Halim, Ershad published their research in PLoS One in 2021. The article was titled 《A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study》.Related Products of 100-83-4 The article contains the following contents:
A convenient approach to synthesis 3-m-tolyl-5-arylidene-2,4-thiazolidinediones (TZDs) I [R = 3-OH, 2-MeO, 2-Cl, 3-Cl, 2-2ON] derivatives in two steps with moderate to good yield using morpholine as a catalyst was reported. All the structures I were confirmed by their spectral IR, 1H NMR and 13C NMR data. The anti-diabatic activity of all synthesized mols. I was evaluated by docking with peroxisome proliferator-activated receptor-γ (PPARγ). Preliminary flexible docking studies revealed that compounds I [R = 3-OH, 2-MeO, 4-Cl] showed better binding affinity with the protein and could be a potential candidate for the treatment of type 2 diabetes in near future. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Related Products of 100-83-4
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