《New approach for the one-pot synthesis of 1,3,5-triazine derivatives: Application of Cu(I) supported on a weakly acidic cation-exchanger resin in a comparative study》 was written by Havrankova, Eva; Csollei, Jozef; Pazdera, Pavel. Related Products of 156-87-6This research focused ontriazine preparation one pot synthesis copper acidic resin catalyst; 1,3,5-triazine; Ullmann reaction; one-pot synthesis; supported Cu(I) catalyst. The article conveys some information:
An efficient and simple methodol. for Ullmann Cu(I)-catalyzed synthesis of di- and trisubstituted 1,3,5-triazine derivatives from dichlorotriazinyl benzenesulfonamide and nucleophiles is reported. Cations Cu(I)-supported on macroporous and weakly acidic, low-cost industrial resin of polyacrylate type were used as a catalyst. The reaction times and yields were compared with traditional synthetic methods for synthesis of the substituted 1,3,5-triazine derivatives via nucleophilic substitution of chlorine atoms in dichlorotriazinyl benzenesulfonamide. It was found that Ullmann-type reactions provide significantly shortened reaction times and, in some cases, also higher yields. Finally, trisubstituted s-triazine derivatives were effectively prepared via Ullmann-type reaction in a one-pot synthetic design. Six new s-triazine derivatives with potential biol. activity were prepared and characterized. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Related Products of 156-87-6)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 156-87-6
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