In 2019,Small included an article by Cao, Shoupeng; Shao, Jingxin; Xia, Yifeng; Che, Hailong; Zhong, Zhiyuan; Meng, Fenghua; van Hest, Jan C. M.; Abdelmohsen, Loai K. E. A.; Williams, David S.. Safety of 3-Bromopropan-1-ol. The article was titled 《Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers》. The information in the text is summarized as follows:
Engineering biodegradable nanostructures with precise morphol. characteristics is a key objective in nanomedicine. In particular, asym. (i.e., nonspherical) nanoparticles are desirable due to the advantageous effects of shape in a biomedical context. Using mol. engineering, it is possible to program unique morphol. features into the self-assembly of block copolymers (BCPs). However, the criteria of biocompatibility and scalability limit progress due to the prevalence of nondegradable components and the use of toxic solvents during fabrication. To address this shortfall, a robust strategy for the fabrication of morphol. asym. nanoworms, comprising biodegradable BCPs, has been developed. Modular BCPs comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-PCLgTMC), with a terminal chain of quaternary ammonium-TMC (PTMC-Q), undergo self-assembly via direct hydration into well-defined nanostructures. By controlling the solution ionic strength during hydration, particle morphol. switches from spherical micelles to nanoworms (of varying aspect ratio). This ionically-induced switch is driven by modulation of chain packing with salts screening interchain repulsions, leading to micelle elongation. Nanoworms can be loaded with cytotoxic cargo (e.g., doxorubicin) at high efficiency, preferentially interact with cancer cells, and increase tumor penetration. This work showcases the ability to program assembly of BCPs and the potential of asym. nanosystems in anticancer drug delivery. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Safety of 3-Bromopropan-1-ol)
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Safety of 3-Bromopropan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts