In 2018,ChemMedChem included an article by Bian, Linglin; Cao, Shining; Cheng, Lihong; Nakazaki, Atsuo; Nishikawa, Toshio; Qi, Jianhua. Computed Properties of C7H6O3. The article was titled 《Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives》. The information in the text is summarized as follows:
(3S,4R)-23,28-Dihydroxyolean-12-en-3-yl (2E)-3-(3,4-dihydroxyphenyl)acrylate (1a), which possesses significant neuritogenic activity, was isolated from the traditional Chinese medicine (TCM) plant, Desmodium sambuense. To confirm the structure and to assess biol. activity, the authors semi-synthesized 1a from com. available oleanolic acid. A series of novel 1a derivatives was then designed and synthesized for a structure-activity relationship (SAR) study. All synthetic derivatives were characterized by anal. of spectral data, and their neuritogenic activities were evaluated in assays with PC12 cells. The SAR results indicate that the number and position of the hydroxy groups on the Ph ring and the triterpene moiety, as well as the length of the (saturated or unsaturated) alkyl chain that links the Ph ring with the triterpene critically influence neuritogenic activity. Among all the tested compounds, 1e [(3S,4R)-23,28-dihydroxyolean-12-en-3-yl (2E)-3-(3,4,5-trihydroxyphenyl)acrylate] was found to be the most potent, inducing significant neurite outgrowth at 1 μM. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Computed Properties of C7H6O3)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Computed Properties of C7H6O3
Referemce:
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Alcohols – Chemistry LibreTexts