The author of 《Nickel-catalyzed C-N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling》 were Yue, Huifeng; Zhu, Chen; Shen, Li; Geng, Qiuyang; Hock, Katharina J.; Yuan, Tingting; Cavallo, Luigi; Rueping, Magnus. And the article was published in Chemical Science in 2019. Application In Synthesis of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:
Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, exptl. mechanistic investigations and d. functional theory (DFT) calculations in combination with wavefunction anal. have been performed to understand the catalytic cycle in more detail. The results came from multiple reactions, including the reaction of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Application In Synthesis of 4,4-Diethoxybutan-1-amine)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of 4,4-Diethoxybutan-1-amine
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts