The author of ãA novel phosphonic acid functional polythiophene fluorescent sensor for Ca2+ and its live cell imagingã?were Yang, Ting; Hu, Zhiru; Liu, Jilin; Zhang, Zhiquan; Feng, Guodong. And the article was published in Analytical Methods in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:
Calcium ions are indispensable to various physiol. activities of the body, so the detection of calcium ions is very important. In this work, a new water-soluble polythiophene derivative poly{((thiophene-3,4-diylbis(oxy))bis(propane-3,1-diyl))bis(phosphonic acid)} (PT-PHO) was designed and synthesized via oxidative polymerization with FeCl3. The polymer containing phosphonic acid groups could be used as a “”turn off”” fluorescent sensor for Ca2+ detection. Under optimal conditions, PT-PHO exhibits high selectivity and sensitivity to detect Ca2+ among metal ions. The fluorescence intensity of PT-PHO shows a linear response toward Ca2+ in the range of 0.05-50 μmol L-1 with a limit of detection (LOD) of 44 nmol L-1. In addition, PT-PHO has low toxicity and good biocompatibility. Thus, it could be used for imaging lysosomes in cells and detecting intracellular calcium ions. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Category: alcohols-buliding-blocks)
3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Category: alcohols-buliding-blocks
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