Yadav, Bhavna; Baire, Beeraiah published an article in 2022. The article was titled ãAg(I)-Promoted, Diastereoselective Cyclo-isomerization of N-Alkynyl-7-azaindole-2-carbinols. Selective Synthesis of syn-1,2-Diarylpyrrolo[1,2-a]indol-3-ones and (Z)-8-Benzylideneoxazolo[3′,4”:1,5]pyrrolo[2,3-b]pyridinesã? and you may find the article in Organic Letters.Safety of Oxetan-3-ol The information in the text is summarized as follows:
The design and development of an Ag(I)-promoted, highly diastereoselective cycloisomerization strategy for the synthesis of syn-1,2-diarylpyrrolo[1,2-a]indol-3-ones from N-alkynyl-indole-2-carbinols was reported. The H218O control experiment and identification of 18O-labeled product suggested the involvement of an external water. The 7-azaindole substrates showed a distinct reactivity to give the (Z)-8-benzylideneoxazolo[3′,4′:1,5]pyrrolo[2,3-b]pyridines. Key features of this strategy were its 100% atom economy, access to important heterocycles, diverse substrate scope, yields up to 95%, operationally simple procedure, and distinct reactivity of indole vs 7-azaindoles.Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol) was used in this study.
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol
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