In 2022,Wang, Xiao-Xu; Yu, Lu; Lu, Xi; Zhang, Zhi-Lin; Liu, De-Guang; Tian, Changlin; Fu, Yao published an article in CCS Chemistry. The title of the article was ãNiH-catalyzed reductive hydrocarbonation of enol esters and ethersã?Application of 821-41-0 The author mentioned the following in the article:
Chiral dialkyl carbinols and their derivatives are significant synthetic building blocks in organic chem. and related fields. The development of convenient and efficient methods to access these compounds has long been an important endeavor. Herein, authors report a NiH-catalyzed reductive hydroalkylation and hydroarylation of enol esters and ethers. α-Oxoalkyl organonickel species were generated in situ in a catalytic mode and then participated in cross-coupling with alkyl or aryl halides. This approach enabled C(sp3)-C(sp3) and C(sp3)-C(sp2) bond formation under mild reductive conditions with simple operations, thereby boosting a broad substrate scope and good functional compatibility. Esters of enantioenriched dialkyl carbinols were accessed in a catalytic asym. version. Mechanistic studies demonstrated that this reaction proceeded through a syn-addition of Ni-H intermediate to an enol ester with high regio- and enantioselectivity. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0Application of 821-41-0)
5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Application of 821-41-0
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Alcohols – Chemistry LibreTexts