ãOne-pot Synthesis of 4-Aminocyclohexanol Isomers by Combining a Keto Reductase and an Amine Transaminaseã?was written by Sviatenko, Olha; Rios-Lombardia, Nicolas; Moris, Francisco; Gonzalez-Sabin, Javier; Venkata Manideep, Kollipara; Merdivan, Simon; Guenther, Sebastian; Suess, Philipp; Hoehne, Matthias. Recommanded Product: trans-4-AminocyclohexanolThis research focused ontransaminase ketoreductase aminocyclohexanol cascade enantioselective synthesis. The article conveys some information:
The efficient multifunctionalization by one-pot or cascade catalytic systems has developed as an important research field, but is often challenging due to incompatibilities or cross-reactivities of the catalysts leading to side product formation. Herein we report the stereoselective preparation of cis- and trans-4-aminocyclohexanol from the potentially bio-based precursor 1,4-cyclohexanedione. We identified regio- and stereoselective enzymes catalyzing reduction and transamination of the diketone, which can be performed in a one-pot sequential or cascade mode. For this, we identified regioselective keto reductases for the selective mono reduction of the diketone to give 4-hydroxycyclohexanone. The system is modular and by choosing stereocomplementary amine transaminases, both cis- and trans-4-aminocyclohexanol were synthesized with good to excellent diastereomeric ratios. Furthermore, we identified an amine transaminase that produces cis-1,4-cyclohexanediamine with diastereomeric ratios >98 : 2. These examples highlight that the high selectivity of enzymes enable short and stereoselective cascade multifunctionalizations to generate high-value building blocks from renewable starting materials. Introduction. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: trans-4-Aminocyclohexanol)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of âOH, such as RC(=O)â? RS(O)2â? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ?; the products are amides of the corresponding acids.Recommanded Product: trans-4-Aminocyclohexanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts