The author of ãAn efficient multicomponent synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a magnetic nanoparticle supported Lewis acidic deep eutectic solventã?were Nguyen, Thanh Thi; Thi Le, Ngoc-Phuong; Nguyen, The Thai; Tran, Phuong Hoang. And the article was published in RSC Advances in 2019. Computed Properties of C7H6O2 The author mentioned the following in the article:
A mild and highly efficient reaction for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles I (R = 2-hydroxyphenyl, 2-fluorophenyl, 1H-indol-3-yl, etc.; R1 = H, phenyl) catalyzed by a magnetically supported Lewis acidic deep eutectic solvent on magnetic nanoparticles (LADES@MNP) has been developed via one-pot multicomponent processes under solvent-free sonication. These reactions have good to excellent yields, mild conditions, and work-up simplicity. This method represents a new method for the preparation of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles I. More importantly, LADES@MNP can be easily recovered by magnetic separation and reused five times without significant loss of catalytic activity. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Computed Properties of C7H6O2
Referemce:
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Alcohols – Chemistry LibreTexts