In 2022,Mansawat, Woraluk; Yukhet, Phanomsak; Bhanthumnavin, Worawan; Reiser, Oliver; Vilaivan, Tirayut published an article in Synlett. The title of the article was ãKinetic Resolution of dl-Hydrobenzoins Catalyzed by Copper(II) Complexes of C2-Symmetric Thiophene-Derived Ligandsã?SDS of cas: 126456-43-7 The author mentioned the following in the article:
C2-Sym. chiral amino alc. ligands with a central thiophene moiety were shown to be effective in combination with CuCl2 for the asym. acylation of dl-hydrobenzoins. In contrast to previously developed chiral ligands, readily available acetyl chloride and acetic anhydride can be used as reagents, in addition to benzoyl chloride, giving rise to the corresponding monoacylated products in up to 99% ee ( S= 532). The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of âOH, such as RC(=O)â? RS(O)2â? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ?; the products are amides of the corresponding acids.SDS of cas: 126456-43-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts