ãDual-Degradable Biohybrid Microgels by Direct Cross-Linking of Chitosan and Dextran Using Azide-Alkyne Cycloadditionã?was published in Biomacromolecules in 2020. These research results belong to Li, Helin; Li, Xin; Jain, Puja; Peng, Huan; Rahimi, Khosrow; Singh, Smriti; Pich, Andrij. Name: 3-Bromopropan-1-ol The article mentions the following:
In this work, biocompatible and degradable biohybrid microgels based on chitosan and dextran were synthesized for drug delivery applications. Two kinds of bio-based building blocks, alkyne-modified chitosan and azide-modified dextran, were used to fabricate microgels via single-step crosslinking in water-in-oil emulsions. The crosslinking was initiated in the presence of copper(II) without the use of any extra crosslinkers. A series of pH-responsive and degradable microgels were successfully synthesized by varying the degree of crosslinks. The microgels were characterized using 1H NMR and FTIR spectroscopy which proved the successful crosslinking of alkyne-modified chitosan and azide-modified dextran by copper(II)-mediated click reaction. The obtained microgels exhibit polyampholyte character and can carry pos. or neg. charges in aqueous solutions at different pH values. Biodegradability of microgels was shown at pH 9 or in the presence of Dextranase due to the hydrolysis of carbonate esters in the microgels or 1,6-α-glucosidic linkages in dextran structure, resp. Furthermore, the microgels could encapsulate vancomycin hydrochloride (VM), an antibiotic, with a high loading of approx. 93.67% via electrostatic interactions. The payload could be released in the presence of Dextranase or under an alk. environment, making the microgels potential candidates for drug delivery, such as colon-specific drug release. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Name: 3-Bromopropan-1-ol)
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Name: 3-Bromopropan-1-ol
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