Kimoto, Michiko; Soh, Si Hui Gabriella; Tan, Hui Pen; Okamoto, Itaru; Hirao, Ichiro published an article on January 31 ,2021. The article was titled ãCognate base-pair selectivity of hydrophobic unnatural bases in DNA ligation by T4 DNA ligaseã? and you may find the article in Biopolymers.COA of Formula: C3H6O2 The information in the text is summarized as follows:
We present cognate base pair selectivity in template-dependent ligation by T4 DNA ligase using a hydrophobic unnatural base pair (UBP), Ds-Pa. T4 DNA ligase efficiently recognizes the Ds-Pa pairing at the conjugation position, and Ds excludes the noncognate pairings with the natural bases. Our results indicate that the hydrophobic base pairing is allowed in enzymic ligation with higher cognate base-pair selectivity, relative to the hydrogen-bond interactions between pairing bases. The efficient ligation using Ds-Pa can be employed in recombinant DNA technol. using genetic alphabet expansion, toward the creation of semi-synthetic organisms containing UBPs. In addition to this study using (R)-Oxiran-2-ylmethanol, there are many other studies that have used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4COA of Formula: C3H6O2) was used in this study.
(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.COA of Formula: C3H6O2
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