Kappauf, Katrin; Majstorovic, Nikola; Agarwal, Seema; Rother, Dorte; Claassen, Christiane published an article in 2021. The article was titled ãModulation of Transaminase Activity by Encapsulation in Temperature-Sensitive Poly(N-acryloyl glycinamide) Hydrogelsã? and you may find the article in ChemBioChem.Safety of 3-Hydroxybenzaldehyde The information in the text is summarized as follows:
Smart hydrogels hold much potential for biocatalysis, not only for the immobilization of enzymes, but also for the control of enzyme activity. We investigated upper critical solution temperature-type poly N-acryloyl glycinamide (pNAGA) hydrogels as a smart matrix for the amine transaminase from Bacillus megaterium (BmTA). Phys. entrapment of BmTA in pNAGA hydrogels results in high immobilization efficiency (>89%) and high activity (97%). The temperature-sensitiveness of pNAGA is preserved upon immobilization of BmTA and shows a gradual deswelling upon temperature reduction While enzyme activity is mainly controlled by temperature, deactivation tended to be higher for immobilized BmTA (=62-68%) than for free BmTA (=44%), suggesting a deactivating effect due to deswelling of the pNAGA gel. Although the deactivation in response to hydrogel deswelling is not yet suitable for controlling enzyme activity sufficiently, it is nevertheless a good starting point for further optimization. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde)
3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Safety of 3-Hydroxybenzaldehyde
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts