The author of ãNi-Catalyzed reductive arylalkylation of unactivated alkenesã?were Jin, Youxiang; Wang, Chuan. And the article was published in Chemical Science in 2019. Synthetic Route of C3H7BrO The author mentioned the following in the article:
In this protocol Ni-catalyzed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides was accomplished, which provided a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes I [R1 = Me, Et, i-Pr, cyclohexyl; R2 = H, Me, Et; R3 = 5-OMe, 5-F, 4-Cl, etc.; R4 = CN, OAc, F, etc.; X = CH2, NH, NMe, O; m = 0,3,4,5,6; n = 0,1]. Notably, this new method circumvented the pregeneration of organometallics and demonstrated high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggested a reaction pathway with an intermediate reduction In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9Synthetic Route of C3H7BrO) was used in this study.
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Synthetic Route of C3H7BrO
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